Diverse Glycosides from Gardenia latifolia with Antiviral Activity and Chemosystematic Significance

نویسندگان

چکیده

Abstract Several influenza pandemics have impacted our life, each with variable prevalence and severity. In a search for natural antivirals, further phytochemical investigation of Gardenia latifolia Aiton, Rubiaceae, was conducted. As result, five structurally diverse glycosides were isolated, offering valuable chemotaxonomic data. Using the crystal violet technique, three isolates, canthoside C, (6 R ,7 S ,8 )-7?-[(?- d -glucopyranosyl) oxy] lyoniresinol, ecdysanrosin A, evaluated their anti-influenza A (H1N1) activities. Based on previously reported anti-inflammatory activity guaiane class, we investigated inhibitory effect (1 ,10 )-7,8,11-trihydroxy-guai-4-ene-3-one 8- O -?- -glucopyranoside, rare sesquiterpene glucoside, inducible nitric oxide (NO) production by Griess assay. Regarding antiviral assay, C most active. It considerably inhibited H1N1 infectivity at an IC 50 value 10.93 µg/ml, showing selectivity index (SI) 12.88, compared acyclovir as standard. Besides, displayed moderate selective 28.03 µg/ml. Considering low cytotoxicity host cells, additional merit potential agents. Despite claimed guaianes, -glucopyranoside showed limited activity.

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ژورنال

عنوان ژورنال: Revista Brasileira de Farmacognosia

سال: 2022

ISSN: ['1981-528X', '0102-695X']

DOI: https://doi.org/10.1007/s43450-022-00335-w